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KMID : 0603820140200010008
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Journal of Experimental & Biomedical Science
2014 Volume.20 No. 1 p.8 ~ p.13
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The Serum Concentrations of YKL-40, IL-6, and TNF-α in Retired Workers Exposed to Inorganic Dusts
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Lee Kyung-Myung
Shin Jae-Hoon
Hwang Joo-Hwan
Lee Jong-Seong
Choi Byung-Soon
Kim In-Sik
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Abstract
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Occupational long-term exposure to inorganic dusts may cause a variety of lung diseases such as pneumoconiosis and chronic obstructive pulmonary disease (COPD). Diagnosis of pneumoconiosis and COPD, however, is currently dependent on radiological findings and pulmonary test, which are both late diagnostic tools. Therefore, there is a need to identify novel biomarkers in pneumoconiosis and COPD. Hence, in this current study we investigated the serum concentrations of YKL-40, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) as biomarkers for pneumoconiosis and COPD in 161 retired male workers exposed to inorganic dusts. The serum concentration of YKL-40 was significantly increased with age, pneumoconiosis, and airflow limitation. The serum concentration of IL-6 was significantly higher in airflow limitation. These results suggest that serum concentration of YKL-40 is associated with age, pneumoconiosis, and airflow limitation. Also, serum concentration of IL-6 is associated with airflow limitation.
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KEYWORD
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YKL-40, IL-6, TNF-α, COPD, Pneumoconiosis
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